Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1
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چکیده
منابع مشابه
Intermittent hypoxia reduces microglia proliferation and induces DNA damage in vitro
Objective(s):Intermittent hypoxia (IH), caused by obstructive sleep apnea (OSA), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. Thus, the present study aimed to explore the effect of IH on the biological functions of microglia cells. Materials and Methods:Cell proliferation of BV2 cells after exposure to IH were o...
متن کاملHypoxia and the DNA Damage Response
Gradients of hypoxia occur in most solid tumors. Cells found in these regions are associated with the most aggressive and therapy-resistant fractions of the tumor. Severe levels of hypoxia (< 0.1 % O2) have been found to induce a unique DNA damage response (DDR) that includes bothATRandATM-mediated signaling. The consequences of the hypoxia-induced DDR include p53-dependent apoptosis and mainte...
متن کاملintermittent hypoxia reduces microglia proliferation and induces dna damage in vitro
objective(s):intermittent hypoxia (ih), caused by obstructive sleep apnea (osa), could cause hippocampus or neuron damage through multiple signaling pathways, while the underlying mechanisms are still unclear. thus, the present study aimed to explore the effect of ih on the biological functions of microglia cells. materials and methods:cell proliferation of bv2 cells after exposure to ih were o...
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Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.13.12059